Professor Ric Price
Professor of global health; senior principal research fellow; staff specialist in infectious diseases and general medicine, Division of Medicine, Royal Darwin Hospital
Qualifications:
Bachelor of Arts, University of Cambridge, 1983; Bachelor of Medicine and Bachelor of Surgery, University of Cambridge, 1989; Master of Arts, University of Cambridge, 1990; Medical Doctorate, University of London, 2000; Fellow of The Royal Australian College of Physicians, 2004; Fellow of The Royal College of Physicians, UK, 2005; Fellow of The Royal College of Pathologists, UK, 2008; Fellow of the Academy of Medical Science, UK, 2019; ASTMH Distinguished International Fellow, USA, 2020
Approved level of HDR supervision at Charles Darwin University:
Principal Supervisor for PhD
Location:
Darwin - Royal Darwin Hospital campus
Biography:
Professor Ric Price is an infectious disease and general physician on the staff at the Royal Darwin Hospital. He holds a dual academic affiliation as professor of global health at the Menzies School of Health Research and professor of tropical medicine at the Centre of Tropical Medicine, University of Oxford, UK.
He is an expert in malaria therapeutics, antimalarial drug resistance and P. vivax epidemiology with a translational research agenda that spans clinical drug trials, epidemiology, parasitology, molecular biology, social science and health economics.
The ultimate aim of Ric’s research is to change public health policy and impact upon global health outcomes. To achieve this he is coordinating a program involving collaborators from 32 countries, working with local partners to provide the evidence needed to optimise policy and practice, building in-country research capacity and strengthening national malaria surveillance systems to support the global elimination of malaria.
Professor Price chairs the clinical module of the World Wide Antimalarial Resistance Network (WWARN) and between 2010-2020, co-chaired the Vivax Working Group of the Asia-Pacific Malaria Elimination Network (APMEN).
In 2021, Ric was elected as a Fellow of the Australian Academy of Health and Medical Sciences.
Research Themes
Overall goals of the program:
- To optimise the management of multidrug resistant malaria
- Define the morbidity and mortality of Plasmodium vivax
- Improve the safe and effective radical cure of P. vivax
- Improve the diagnosis and surveillance of G6PD deficiency
- Define molecular mechanisms of drug resistant Plasmodia
Clinical trials:
- IMPROV Study: Shorter treatment regimen for radical cure of P.Vivax malaria
- EFFORT clinical trial: Effectiveness of tafenoquine and primaquine
- PRIMA clinical trial: Universal Radical Cure of P. vivax malaria
- SIRIN Clinical Trial: Radical cure of P. vivax malaria in Nepal
- The Tropical Disease Regional Research Regional Collaborative Initiative: Responding to Drug-Resistant Tuberculosis and Malaria in the Asia-Pacific
Epidemiology:
- vivaxGEN: Molecular surveillance of P. vivax
- ACROSS Study: Populations at risk of malaria and drug induced haemolysis
Stronger Health and Research Systems:
- Devine, A., Battle, K. E., Meagher, N., Howes, R. E., Dini, S., Gething, P. W., Simpson, J. A., Price, R. N., & Lubell, Y. (2021). Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study. PLoS medicine, 18(6), e1003614. https://doi.org/10.1371/journal.pmed.1003614
- Pfeffer, D. A., Ley, B., Howes, R. E., Adu, P., Alam, M. S., Bansil, P., Boum, Y., Brito, M., Charoenkwan, P., Clements, A., Cui, L., Deng, Z., Egesie, O. J., Espino, F. E., von Fricken, M. E., Hamid, M., He, Y., Henriques, G., Khan, W. A., Khim, N.…Price, R. N. (2020). Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis. PLoS medicine, 17(5), e1003084. https://doi.org/10.1371/journal.pmed.1003084
- Taylor, W., Thriemer, K., von Seidlein, L., Yuentrakul, P., Assawariyathipat, T., Assefa, A….Price, R. N. (2019). Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial. The Lancet, 394(10202), 929-938. https://doi.org/10.1016/s0140-6736(19)31285-1
- Hossain, M. S., Commons, R. J., Douglas, N. M., Thriemer, K., Alemayehu, B. H., Amaratunga, C., Anvikar, A. R., Ashley, E. A., Asih, P., Carrara, V. I., Lon, C., D'Alessandro, U., Davis, T., Dondorp, A. M., Edstein, M. D., Fairhurst, R. M., Ferreira, M. U., Hwang, J., Janssens, B., Karunajeewa, H.…Price, R. N. (2020). The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. PLoS medicine, 17(11), e1003393. https://doi.org/10.1371/journal.pmed.1003393
- Commons, R. J., Simpson, J. A., Thriemer, K., Humphreys, G. S., Abreha, T., Alemu, S. G., Añez, A., Anstey, N. M., Awab, G. R., Baird, J. K., Barber, B. E., Borghini-Fuhrer, I., Chu, C. S., D'Alessandro, U., Dahal, P., Daher, A., de Vries, P. J., Erhart, A., Gomes, M., Gonzalez-Ceron, L.…Price, R. N. (2018). The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis. The Lancet. Infectious diseases, 18(9), 1025–1034. https://doi.org/10.1016/S1473-3099(18)30348-7
- Auburn, S., Benavente, E., Miotto, O., Pearson, R., Amato, R., Grigg, M….Price, R. N. (2018). Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-04965-4
- Douglas, N. M., Poespoprodjo, J. R., Patriani, D., Malloy, M. J., Kenangalem, E., Sugiarto, P., Simpson, J. A., Soenarto, Y., Anstey, N. M., & Price, R. N. (2017). Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study. PLoS medicine, 14(8), e1002379. https://doi.org/10.1371/journal.pmed.1002379
- Abreha, T., Hwang, J., Thriemer, K., Tadesse, Y., Girma, S., Melaku, Z….Price, R. N. (2017). Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial. PLOS Medicine, 14(5), e1002299. https://doi.org/10.1371/journal.pmed.1002299
- Price, R. N., von Seidlein, L., Valecha, N., Nosten, F., Baird, J. K., & White, N. J. (2014). Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis. The Lancet. Infectious diseases, 14(10), 982–991. https://doi.org/10.1016/S1473-3099(14)70855-2
- Ratcliff, A., Siswantoro, H., Kenangalem, E., Maristela, R., Wuwung, R. M., Laihad, F., Ebsworth, E. P., Anstey, N. M., Tjitra, E., & Price, R. N. (2007). Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison. Lancet (London, England), 369(9563), 757–765. https://doi.org/10.1016/S0140-6736(07)60160-3
- Price, R. N., Uhlemann, A. C., Brockman, A., McGready, R., Ashley, E., Phaipun, L., Patel, R., Laing, K., Looareesuwan, S., White, N. J., Nosten, F., & Krishna, S. (2004). Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet (London, England), 364(9432), 438–447. https://doi.org/10.1016/S0140-6736(04)16767-6
- Price, R. N., Nosten, F., Luxemburger, C., ter Kuile, F. O., Paiphun, L., Chongsuphajaisiddhi, T., & White, N. J. (1996). Effects of artemisinin derivatives on malaria transmissibility. Lancet (London, England), 347(9016), 1654–1658. https://doi.org/10.1016/s0140-6736(96)91488-9